Severe cases of pandemic (H1N1) 2009 in children, Germany.
Identifieur interne : 000284 ( Main/Exploration ); précédent : 000283; suivant : 000285Severe cases of pandemic (H1N1) 2009 in children, Germany.
Auteurs : Mathias Altmann [Allemagne] ; Lena Fiebig ; Jana Soyka ; Rüdiger Von Kries ; Manuel Dehnert ; Walter HaasSource :
- Emerging infectious diseases [ 1080-6059 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Allemagne (épidémiologie), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Facteurs de risque (MeSH), Grippe humaine (mortalité), Grippe humaine (physiopathologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains (MeSH), Indice de gravité de la maladie (MeSH), Nourrisson (MeSH), Pandémies (MeSH), Prévalence (MeSH), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sous-type H1N1 du virus de la grippe A (pathogénicité), Unités de soins intensifs pédiatriques (statistiques et données numériques).
- MESH :
- génétique : Sous-type H1N1 du virus de la grippe A.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- mortalité : Grippe humaine.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- physiopathologie : Grippe humaine.
- statistiques et données numériques : Unités de soins intensifs pédiatriques.
- virologie : Grippe humaine.
- épidémiologie : Allemagne, Grippe humaine.
- Adolescent, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Humains, Indice de gravité de la maladie, Nourrisson, Pandémies, Prévalence.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Adolescent (MeSH), Child (MeSH), Child, Preschool (MeSH), Germany (epidemiology), Humans (MeSH), Infant (MeSH), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (mortality), Influenza, Human (physiopathology), Influenza, Human (virology), Intensive Care Units, Pediatric (statistics & numerical data), Pandemics (MeSH), Prevalence (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH).
- MESH :
- geographic , epidemiology : Germany.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- mortality : Influenza, Human.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- physiopathology : Influenza, Human.
- statistics & numerical data : Intensive Care Units, Pediatric.
- virology : Influenza, Human.
- Adolescent, Child, Child, Preschool, Humans, Infant, Pandemics, Prevalence, Risk Factors, Severity of Illness Index.
Abstract
In a hospital-based observational study in Germany, we investigated children admitted to pediatric intensive care units and deaths caused by confirmed pandemic (H1N1) 2009 to identify risk factors and outcomes in critically ill children. Ninety-three children were eligible for our study, including 9 with hospital-acquired infections. Seventy-five percent had underlying chronic medical conditions; neurodevelopmental disorders were most prevalent (57%). The proportion of patients having ≥1 risk factor increased with age in years (odds ratio 1.21, p = 0.007). Of 15 deaths, 11 occurred in a pediatric intensive care unit (case-fatality rate 12%, 95% confidence interval 6%-21%). Only 9% of the children had been vaccinated against pandemic (H1N1) 2009; all survived. Our results stress the role of underlying risk factors, especially neurodevelopmental disorders, and the need for improving preventive measures to reduce severe disease and adverse outcomes of pandemic (H1N1) 2009 in children.
DOI: 10.3201/eid1702.101090
PubMed: 21291587
PubMed Central: PMC3204773
Affiliations:
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Ninety-three children were eligible for our study, including 9 with hospital-acquired infections. Seventy-five percent had underlying chronic medical conditions; neurodevelopmental disorders were most prevalent (57%). The proportion of patients having ≥1 risk factor increased with age in years (odds ratio 1.21, p = 0.007). Of 15 deaths, 11 occurred in a pediatric intensive care unit (case-fatality rate 12%, 95% confidence interval 6%-21%). Only 9% of the children had been vaccinated against pandemic (H1N1) 2009; all survived. Our results stress the role of underlying risk factors, especially neurodevelopmental disorders, and the need for improving preventive measures to reduce severe disease and adverse outcomes of pandemic (H1N1) 2009 in children.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21291587</PMID><DateCompleted><Year>2011</Year><Month>05</Month><Day>19</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1080-6059</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Emerging infectious diseases</Title><ISOAbbreviation>Emerging Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Severe cases of pandemic (H1N1) 2009 in children, Germany.</ArticleTitle><Pagination><MedlinePgn>186-92</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3201/eid1702.101090</ELocationID><Abstract><AbstractText>In a hospital-based observational study in Germany, we investigated children admitted to pediatric intensive care units and deaths caused by confirmed pandemic (H1N1) 2009 to identify risk factors and outcomes in critically ill children. Ninety-three children were eligible for our study, including 9 with hospital-acquired infections. Seventy-five percent had underlying chronic medical conditions; neurodevelopmental disorders were most prevalent (57%). The proportion of patients having ≥1 risk factor increased with age in years (odds ratio 1.21, p = 0.007). Of 15 deaths, 11 occurred in a pediatric intensive care unit (case-fatality rate 12%, 95% confidence interval 6%-21%). Only 9% of the children had been vaccinated against pandemic (H1N1) 2009; all survived. Our results stress the role of underlying risk factors, especially neurodevelopmental disorders, and the need for improving preventive measures to reduce severe disease and adverse outcomes of pandemic (H1N1) 2009 in children.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Altmann</LastName><ForeName>Mathias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department for Infectious Disease Epidemiology, Respiratory Infections Unit, Robert Koch Institute, Postfach 65 02 61, 13302 Berlin, Germany. altmannm@rki.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiebig</LastName><ForeName>Lena</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Soyka</LastName><ForeName>Jana</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>von Kries</LastName><ForeName>Rüdiger</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Dehnert</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Haas</LastName><ForeName>Walter</ForeName><Initials>W</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Emerg Infect Dis</MedlineTA><NlmUniqueID>9508155</NlmUniqueID><ISSNLinking>1080-6040</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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last="Dehnert">Manuel Dehnert</name><name sortKey="Fiebig, Lena" sort="Fiebig, Lena" uniqKey="Fiebig L" first="Lena" last="Fiebig">Lena Fiebig</name><name sortKey="Haas, Walter" sort="Haas, Walter" uniqKey="Haas W" first="Walter" last="Haas">Walter Haas</name><name sortKey="Soyka, Jana" sort="Soyka, Jana" uniqKey="Soyka J" first="Jana" last="Soyka">Jana Soyka</name><name sortKey="Von Kries, Rudiger" sort="Von Kries, Rudiger" uniqKey="Von Kries R" first="Rüdiger" last="Von Kries">Rüdiger Von Kries</name></noCountry><country name="Allemagne"><region name="Berlin"><name sortKey="Altmann, Mathias" sort="Altmann, Mathias" uniqKey="Altmann M" first="Mathias" last="Altmann">Mathias Altmann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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